The buzzing Barrio Getsemaní is, perhaps, Cartagena's most attractive neighbourhood, for both its well-preserved colonial architecture and vivid street life. Known as the nightlife hotspot of Cartagena, Getsemaní stays up until late at night, with locals and visitors mingling in and around Plaza de la Trinidad over drinks and street food.

A feat of Spanish colonial military architecture, the Castillo San Felipe de Barajas is one of Cartagena's most prized attractions. The fortress, whose construction finished in the late 18th century, was never seized — and not for a lack of attempted forays. Part of its sophisticated system of underground tunnels is open to the public. A guided tour (audio guides available) is highly recommended.

Cagliari Cathedral is a Roman Catholic church which was constructed in the 13th century in Pisan-Romanesque style and restored during the 1930s. Walking along its nave, you can admire the amazing marble elements, which provide the building with an enchanting aura, as well as the two astonishing pulpits sculpted by Guglielmo da Pisa.

While seasoned travellers may venture into Cartagena's gritty Bazurto Market on their own, those not yet toughened by locals-only markets of the region may prefer to explore as part of a guided tour. This sprawling market, where trade starts before the crack of dawn, features incredibly fresh produce and seafood from Cartagena and beyond. Much of it makes its way to the tables of local fine dining establishments within the space of the same day. There is plenty to look at and taste, including local street food and multiple succulent varieties of tropical fruit you're unlikely to have encountered before.