Museum Boijmans Van Beuningen is one of the oldest museums in the Netherlands. Throughout the year, the museum hosts a rich spectrum of temporary exhibits on a variety of subjects. Besides that, the collection of paintings, sculptures, drawings, etchings and objects is impressive. It features many major Dutch and European works spanning the period from the early middle ages to the 21st century, from Jeroen Bosch to Rembrandt and from Van Gogh to Salvador Dalí and Dutch Design. The museum building is closed for major renovation, but the entire collection of 145,000 objects accessible to the public in other museums. Within the Museumpark, Museum Boijmans Van Beuningen has built an art depot: Depot Boijmans Van Beuningen.

Once the hidden seat of the African National Congress (the South African social democratic party which has been in power post-apartheid), the building has now been transformed into a high-tech, interactive museum dedicated to the nation's struggle with racial equality.

The site of an infamous prison reborn as the superb Constitutional Court, art gallery and museum. The history of Constitution Hill dates back to 1892; a prison turned military defence post during the South African War. These buildings were known as "the Fort", and have through the years incarcerated the likes of Mahatma Gandhi. In 1964 the Fort was declared a National Monument, and in the late 90's it was chosen the new Constitutional Court.