Built on the land occupied earlier by the Corpus Christi hospital, one of the city's medieval hospitals. In 1558 the city exchanged plots with Archishop Esteban Almeyda and the hospital was relocated to the Parish of Santiago. The building may have started in the 16th Century, soon after the establishment of the Orihuela Bishopric. It underwent profound changes in the 18th Century under the reigns of Bishops José Flores Ososrio and Pedro Albornoa Tapia. In the mid-20th century, it lost its original functions, was restored at the beginning of the 21st Century and is currently home to the Diocese Museum of Sacred Art. At the back, facing the river, there is a gallery with semi-circular arches. Inside, another striking feature is the cloister with heraldic decoration, the main staircase of Alicante marble and the dome built on an octagonal base, with exterior cobalt blue glazed tiles.

This museum provides an interesting opportunity to get an overview of the history of Trieste as a city born of the sea. In connection to that, a comprehensive exhibition of reproductions of different types of ships and means of navigation.

The Orihuela Archaeology Museum has its origins in the former Santo Domingo Museum of Antiquities, established in 1902 by Jesuit priest Julio Furgús, who donated numerous pieces. Created by the Orihuela Town Council, the museum has been housed in various locations, including the Palacio de Teodomiro, the Municipal Hospital, the Rubalcaba Palace, and since 1997, its current location at the Church of San Juan de Dios, which was built in the mid-18th century. The museum's collection features artefacts that span a broad range of periods, from the Paleolithic era to the early 19th century. The majority of the items were excavated or discovered in the town and its surrounding areas, often through the museum's own investigations. The same building also houses the Exhibition Hall, formerly the men's ward of the hospital. This spacious, rectangular room with barrel-vaulted ceilings hosts temporary exhibitions and various cultural events.