Aristotelous Square is the most impressive square in Thessaloniki. It features buildings with monumental architecture inspired by European and colonial models, cafes, shops and restaurants. It is the focal point in big celebrations, such as the coming of the New Year, and is the de facto meeting place during the day. The history of Aristotelous Square began with the Great Fire of 1917 that destroyed two thirds of the city. The French architect Ernest Hébrard designed Aristotelous Square to serve as an end of a monumental axis for Thessaloniki that would stretch from the seafront to Dikastirion Square and the Roman Forum. The final design, built in the 1950s, is a lot more stripped down than Hébrard's original proposal, but still has significant architectural value.

Housed inside the former Presidential Palace and decorated by the world-famous Tiffany's, the Museo de la Revolución tells the – admittedly partial – story of the Cuban revolution, with explanations provided in both English and Spanish. Bullet holes remaining after a failed assassination attempt of the palace's last resident, former president Fulgencio Batista, are still clearly visible in the hall area.

This art museum is located in the former Rosario church, next to the Cathedral, and it is the ideal setting for an array of priceless religious art. They also showcase African sacred paintings and artworks.

Housed in the Archbishop's Palace, the Museo Diocesano di Palermo boasts an impressive collection of sculptures from the 15th to 18th centuries. It also displays interesting artworks, such as religious silverware and textiles, frescoes and Italian and Flemish paintings from the 16th to 19th centuries.