Originally built for the Medici family, this palace later passed to the Riccardi family, who expanded it. It’s one of the key spots to see Renaissance architecture up close in Florence. Inside, you’ll find an art museum with frescoes and works that give you a real sense of the city’s past power and wealth.

The Sixth Floor Museum gives visitors an opportunity to explore one of America’s darkest moments: this is the location from which President John F. Kennedy was assassinated, now converted into a museum. Exhibits narrate the life, times and untimely death of president Kennedy. Also located in the museum is the Reading Room, where patrons can delve into audiovisual resources, artifacts and an endless supply of books.

Val d’Orcia conjures up everything you picture when you think of Tuscany—rolling hills, cypress-lined roads, and quiet hill towns. It’s a protected UNESCO site, partly because of the landscape, partly because of how little it’s changed over the centuries. Pienza is the standout—it was designed as the 'ideal city' during the Renaissance and still feels unusually well put together. The Abbey of Sant’Antimo is a peaceful stop, tucked into the countryside. And if you're into wine, this is Brunello country—some of the best reds in Italy. Even just driving through is half the experience.